ESR 5 (University of Tromsø)

ESR5

University of Tromsø

Project Title:

High speed optical nanoscopy for the optimization of vesicle uptake by liver cells

Objectives:

(1) real time nanoscopy study of LSEC-mediated uptake of vesicles

(2) determination of intracellular fate and optimization of vesicle properties

(3) determination of the factors affecting uptake, particularly gender, age and liver impairment

(4) production of nano vectors for distribution across the network

Expected Results:

(1) Clear understanding of the fate of nano delivery systems and associated drugs in LSEC established

(2) uptake with respect to bioavailability of vector-associated drugs optimized

(3) toxicity and safety of nano delivery systems and their clearance in liver established

(4) effects of gender, age and liver impairment on nano vector uptake, first step to individualized drug therapy established

(5) effects on the morphology and function of isolated LSEC determined

Universität Bielefeld - Biomolecular Photonics - Faculty of Physics - Universitätsstraße 25 - D-33615 Bielefeld - Germany

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