ESR 3 (University of Tromsø)

ESR3

University of Tromsø

Project Title:

Development of a waveguide- and microfluidics-based integrated optical nanoscopy platform

Objectives:

(1) Development of an integrated optics platform for real-time nanoscopic study of LSEC dynamics based on waveguide-SR-SIM

(2) Increase field-of-view for single molecule localization microscopy to 200 µm x 100 µm based on waveguide excitation, implement nonlinear SIM approaches

(3) demonstrate waveguide-integrated nanoscopy with microfluidic delivery for the rapid imaging of small molecule-LSEC interactions

Expected Results:

(1) Waveguide nanoscopy operational and imaging of fixed cells completed (90 nm, 20 frames/s)

(2) field of view of waveguide nanoscopy increased to 200 µm x 100 µm

(3) imaging of interactions of small molecules and nanoparticles with LSECs in vitro demonstrated

Universität Bielefeld - Biomolecular Photonics - Faculty of Physics - Universitätsstraße 25 - D-33615 Bielefeld - Germany

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